Comparative Evaluation of Simple Indices of Graft Function After Islet Transplantation

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Primary Graft Function, Metabolic Control, and Graft Survival After Islet Transplantation

OBJECTIVE To investigate the influence of primary graft function (PGF) on graft survival and metabolic control after islet transplantation with the Edmonton protocol. RESEARCH DESIGN AND METHODS A total of 14 consecutive patients with brittle type 1 diabetes were enrolled in this phase 2 study and received median 12,479 islet equivalents per kilogram of body weight (interquartile range 11,072-1...

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Prevalence of hepatic steatosis after islet transplantation and its relation to graft function.

Islet allotransplantation can provide insulin independence in selected individuals with type 1 diabetes. The long-term effects of these transplants on the liver are unknown. Recently, two cases of periportal steatosis after islet transplantation have been described. In this study, we performed ultrasound and magnetic resonance imaging (MRI) in 30 C-peptide-positive islet transplant recipients t...

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-Score An assessment of -cell function after islet transplantation

OBJECTIVE — Success after islet transplantation can be defined in terms of insulin independence, C-peptide secretion, or glycemic control. These measures are interdependent and all need to be considered in evaluating -cell function after islet transplantation. For the current study, a composite -score was developed that provides an integrated measure of -cell function success after islet transp...

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ژورنال

عنوان ژورنال: Transplantation

سال: 2011

ISSN: 0041-1337

DOI: 10.1097/tp.0b013e31822ca79b